Exploring Biomedical Knowledge-Backed AI With The Orpheus ChatGPT Plugin

In today’s AI-driven world, innovative solutions are continuously reshaping the way we explore, analyze, and apply knowledge in the life sciences.

One of the most prominent AI models at the forefront of this transformation is ChatGPT. As an AI language model, ChatGPT possesses the remarkable ability to understand and generate human-like text. Its versatility and adaptability have made it a valuable tool across various domains, including healthcare and life sciences.

In parallel, Wisecube’s biomedical knowledge graph, Orpheus, stands as a pillar of information, connecting vast networks of biomedical data, literature, and expertise. Orpheus empowers researchers, clinicians, and decision-makers with a wealth of structured biomedical knowledge, enabling them to navigate the complex web of information in the biomedical field.

The synthesis of these two powerful entities—ChatGPT and Orpheus—offers an exciting paradigm shift towards knowledge-backed AI in biomedicine.

In this article, we will navigate the terrain of biomedical knowledge-backed AI, uncovering the concept of a ChatGPT Plugin for Orpheus. We will also delve into its potential in bringing together two powerful technologies to revolutionize the way we conduct research, make clinical decisions, and drive innovation in the biomedical field.

ChatGPT in Biomedicine

The field of biomedical research is an arena where precision and accuracy are of paramount importance, as they directly impact healthcare quality and, ultimately, patient lives. In this critical domain, ChatGPT emerges as a valuable asset with the potential to elevate research endeavors. It can bolster research methodologies, enhance adherence to established standards, and offer readily accessible support, contributing to improved healthcare outcomes. 

Use cases

Here are some of the key biomedical use cases where ChatGPT can make a significant impact:

  • Clinical decision support

ChatGPT empowers medical practitioners with the ability to swiftly access current and pertinent medical information from extensive healthcare data sources. It harnesses this wealth of information to provide recommendations for effective clinical decision-making based on the latest research and patient data. This streamlined approach to diagnosis and treatment planning has the potential to improve accuracy and enhance treatment decisions.

  • Literature analysis

Researchers can harness ChatGPT’s capabilities to navigate extensive volumes of medical literature, extracting and summarizing critical findings, recognizing gaps in knowledge, and proposing avenues for further investigation. This streamlined approach expedites the often time-consuming process of literature review, offering valuable time and resource savings for researchers.

  • Drug discovery

ChatGPT is capable of analyzing vast datasets of molecular information, existing research studies, and clinical trial data for tasks such as target identification, compound screening, and predicting potential drug interactions. It can achieve this by leveraging its advanced deep learning capabilities to recognize patterns and relationships within the data. These patterns enable ChatGPT to pinpoint promising drug candidates, understand their mechanisms, and predict potential interactions with other substances. This analytical prowess significantly accelerates the drug discovery process, streamlining research efforts and enhancing efficiency.

  • Improving patient literacy

ChatGPT is a valuable tool for crafting patient-friendly resources that demystify complex medical conditions and treatment options, presenting them in clear and easily understandable language. This approach not only enhances patient comprehension but also boosts engagement, ensuring that individuals are well-informed and empowered in their healthcare decisions.


Despite its promising potential, ChatGPT is limited by several constraints that can affect its effectiveness and utility in biomedicine.

  • Hallucinations

ChatGPT’s occasional generation of incorrect or hallucinated information can be attributed to the limitations of its training data and the inherent complexity of language understanding. This complexity can sometimes result in the model generating responses that appear plausible but are, in fact, inaccurate, especially in the nuanced domain of medical information.

  • Bias

The potential for bias in AI models like ChatGPT arises from the data used for training, which often reflects the biases present in the real world. In medical contexts, this can be especially problematic, as historical disparities and underrepresentation in healthcare data may lead to biased recommendations. Overcoming this challenge necessitates meticulous curation of training data and the development of algorithms that actively mitigate bias.

  • Lack of domain expertise

ChatGPT, while highly knowledgeable, lacks the domain-specific expertise and nuanced understanding that healthcare professionals possess. Its responses are generated based on patterns in the text it has seen during training, but it doesn’t have the depth of clinical experience or context that medical practitioners bring to their decisions. This limitation is inherent to the AI’s design.

  • Extensive validation required

The rigorous validation and testing required for AI-driven tools like ChatGPT in medical research are imperative to ensure patient safety and the alignment of recommendations with clinical standards. Given the complexity and variability of medical cases, extensive validation is necessary to reduce the potential for errors or unintended outcomes when implementing AI in healthcare settings.

  • Large volumes of medical data to memorize

ChatGPT’s effectiveness is tied to the data it has been trained on, and its limitations emerge when dealing with the vast and ever-evolving field of medicine. The challenge here is to keep the model continuously updated with the latest research, which involves curating and integrating massive amounts of data while maintaining the model’s efficiency.

  • Inability to access confidential medical data 

The inability of AI models like ChatGPT to access confidential medical data stems from the stringent privacy and ethical considerations surrounding healthcare. Protecting patient confidentiality is a fundamental principle, and AI models must adhere to these guidelines, often limiting the depth of knowledge they can access to ensure patient privacy and data security. This can affect their ability to provide comprehensive insights in certain medical scenarios.

Wisecube’s Contribution to Biomedicine-Orpheus

Biomedical relationships knowledge is invaluable for groundbreaking insights and data-driven drug discovery. Yet, this knowledge is often trapped within a multitude of publications and databases, posing significant challenges in terms of collection, organization, and integration, often consuming substantial time and resources.

This is where Wisecube’s Biomedical Knowledge Graph, Orpheus, comes into play. It stands as the largest knowledge graph of its kind, housing billions of facts about millions of biomedical entities. This vast repository is integrated from thousands of sources, made possible by cutting-edge AI technology.

Use cases

Orpheus offers a wealth of applications that hold immense potential for biomedical research and discovery. Its multifaceted capabilities cater to a range of critical use cases, each designed to advance our understanding of the complex world of biomedicine. Some of its use cases include:

  • Relationship Inference with Advanced AI

Orpheus harnesses the power of advanced AI to infer intricate relationships within biomedical data. This function opens doors to deeper insights, enabling researchers to uncover hidden connections and patterns that may have otherwise gone unnoticed.

  • Biomarker Identification 

Using advanced Link prediction and Graph AI techniques, Orpheus aids in the identification of novel biomarkers. This critical capability supports the development of diagnostic tools and therapies, furthering the cause of precision medicine.

  • Lead Discovery

Orpheus plays a pivotal role in lead discovery, helping researchers pinpoint promising candidates for new drugs and treatments. By efficiently analyzing the vast biomedical knowledge within its graph, it streamlines the search for potential breakthroughs.

  • Drug Repurposing

Orpheus excels in the domain of drug repurposing. By revealing concealed biomedical relationships and causal connections, it empowers researchers to identify new therapeutic applications for existing drugs, potentially accelerating the development of novel treatments.

Importance of Bridging the Gap Between Orpheus & ChatGPT

Orpheus, Wisecube’s Biomedical Knowledge Graph, and ChatGPT represent two powerful entities in the realm of medical research and knowledge-driven AI. When these two remarkable platforms converge, the potential for transformative outcomes becomes evident. Orpheus has much to offer in terms of enhancing the strengths of ChatGPT, creating a dynamic synergy that brings profound benefits to the field of biomedicine.

User-friendly interface for interacting with a biomedical knowledge graph in natural language

The fusion of Orpheus and ChatGPT opens the door to a user-friendly interface that allows individuals to interact with a unified biomedical knowledge graph using natural language. Imagine a medical researcher who wishes to explore the intricate web of genetic factors contributing to a specific disease. Through the unified interface, they can simply ask, “What are the key genetic contributors to this disease?” ChatGPT, powered by Orpheus, swiftly retrieves structured data and research findings, offering a user-friendly, natural language response that simplifies the complex medical landscape. This combination eliminates barriers and empowers users to navigate and understand the wealth of information within Orpheus with ease, promoting a more accessible and intuitive approach to biomedical research.

Quick and improved biomedical knowledge retrieval

Orpheus can bolster ChatGPT’s ability to swiftly and efficiently retrieve biomedical knowledge. Consider a scenario where a medical student is researching a rare medical condition characterized by a set of perplexing symptoms. Orpheus, with its vast repository, swiftly provides a wealth of structured information about the condition, including its clinical manifestations, diagnostic criteria, and the latest treatment options. ChatGPT, equipped with this knowledge, can then assist the student by summarizing the critical points, offering insights into emerging research, and even suggesting potential avenues for further investigation. This collaboration streamlines the research process and equips users with quick, accurate, and pertinent insights in response to complex medical queries, ultimately advancing the quality and efficiency of biomedical research and learning.

Sophisticated analysis of structured and accurate biomedical knowledge

Orpheus serves as the bedrock for ChatGPT’s analytical capabilities by providing a structured and highly accurate biomedical knowledge foundation. The significance of this can be exemplified in a scenario where a medical researcher seeks to understand the intricate relationship between a specific gene mutation and a rare disease. Orpheus, with its comprehensive knowledge graph, swiftly offers detailed data, research papers, and clinical findings related to this genetic mutation and its connection to the disease. ChatGPT, with its natural language processing prowess, can then distill this extensive information into a concise and accessible summary, providing the researcher with actionable insights, potential research directions, and a comprehensive understanding of the subject. This collaboration empowers users with dependable, in-depth information, enabling them to make well-informed decisions and delve into complex biomedical inquiries with confidence.

Facilitated decision support

The synergy of Orpheus and ChatGPT extends sophisticated decision support that transcends traditional boundaries. By rapidly providing healthcare professionals with up-to-date research findings and relevant clinical data, this collaboration enhances the quality of healthcare and research outcomes. For instance, a physician dealing with a complex case can swiftly access insights, potential treatment options, and patient-specific information, ultimately improving patient care and advancing the field of biomedicine.

Interactive learning

This powerful collaboration fosters interactive learning, allowing users to engage with and learn from the vast wealth of biomedical knowledge. Consider, for example, a healthcare professional interested in exploring the latest advancements in a specific medical field. With the unified interface, they can engage ChatGPT, asking questions such as, “What are the recent breakthroughs in neurology?” ChatGPT, fueled by Orpheus, not only delivers the latest findings but also encourages the user to ask follow-up questions, delve deeper into specific research papers, and gain a more profound understanding of the subject. This interactive learning experience empowers users to navigate and comprehend complex medical concepts effectively.

ChatGPT Plugin for Orpheus

ChatGPT Plugin

OpenAI’s latest milestone introduces an innovative avenue for enhancing ChatGPT’s capabilities through the introduction of ChatGPT Plugins.

The ChatGPT Plugin feature enables users to seamlessly connect ChatGPT with external knowledge sources, effectively access up-to-date information, run computations, and even employ third-party services. These plugins are aimed at augmenting the AI’s proficiency in providing precise, context-aware responses, signifying a giant leap forward in harnessing AI’s potential for knowledge-backed and domain-specific applications. This expands ChatGPT’s horizon to a wide array of possibilities in diverse sectors, including healthcare and biomedicine.

Components of the Orpheus GPT Plugin

The convergence of the Orpheus Biomedical Knowledge Graph and ChatGPT hints at the boundless possibilities for biomedical knowledge-backed AI, poised to redefine the realm of biomedicine.

This transformative union, where Orpheus and ChatGPT combine their strengths, is made possible through the Orpheus-ChatGPT Plugin. This innovative plugin acts as the catalyst for connection, seamlessly bridging the gap between these two powerful entities. Through the plugin, ChatGPT gains access to the extensive biomedical knowledge housed within Orpheus, and the possibilities for transformative outcomes become vividly apparent.

The Orpheus GPT Plugin is a multifaceted tool that leverages various components to seamlessly connect ChatGPT and Orpheus. These components collectively ensure efficient interaction between the two platforms, while maintaining security and reliability:

  • API Gateways: The gateway component serves as the bridge connecting ChatGPT with Orpheus through their respective beanstalk environments. This component allows for a seamless exchange of information and knowledge using two gateways:
    • Plugin API Gateway facilitates the secure flow of ChatGPT queries to Orpheus’s extensive biomedical knowledge, through the plugin’s beanstalk environment.
    • Orpheus API Gateway enables the plugin to access Orpheus’s vast biomedical knowledge repository for responses, through the Orpheus beanstalk environment.
  • AWS Elastic Beanstalk environment: With an underlying engine built using Python, this environment serves as the hosting platform for the plugin’s codebase. This infrastructure component ensures the Orpheus-ChatGPT plugin’s smooth operation.
  • Authorizer: This component serves a crucial role in user authentication and verification. It ensures that access to the Orpheus-ChatGPT Plugin is limited to authorized users, maintaining the security and integrity of the interaction between ChatGPT and Orpheus.

How to use the Orpheus-ChatGPT Plugin

Before you can harness the transformative power of the Orpheus GPT Plugin, a crucial step awaits—installation. This section will guide you through the process of setting up the plugin, paving the way for a seamless fusion of ChatGPT and Orpheus for biomedical knowledge discovery.

The plugin is available at two endpoints, merely:

Elastic Beanstalk unsecured access path:http://orpheus-adapter.us-east-2.elasticbeanstalk.com/ 

API Gateway secure access path: https://gpt-api.wisecube.ai/ 


Here are the installation steps for the Orpheus-ChatGPT Plugin:

  1. Open ChatGPT. In the bottom left corner, select Settings > Beta Features, then toggle the Plugins setting.
  2. In ChatGPT, select New Chat.
  3. Switch the ChatGPT model to GPT-4.
  4. From the dropdown menu, select Plugins > Plugin Store.
  5. Within the bottom section of the Plugin Store, select Develop Own Plugin.
  6. Type in the publicly available domain path to the plugin.
  7. Proceed with Find manifest file.
  8. From the dropdown menu, select Plugins > Orpheus plugin.
  1. Ask ChatGPT any disease related questions to obtain clinical trials or pubmed articles with the version deployed on 15.06.2023, for example, “What are some clinical trials for carcinoma?”

Sample Results of Using Orpheus ChatGPT Plugin

Future Directions for Biomedical Knowledge-Backed AI

The journey towards knowledge-backed AI is an ongoing one, with continuous advancements on the horizon. As AI models and plugins become more integrated with domain-specific knowledge, we can anticipate unprecedented possibilities for research, healthcare, and beyond.

In this regard, the integration of ChatGPT with the Orpheus through a ChatGPT plugin marks a significant stride towards realizing the potential of knowledge-backed AI in biomedicine. As ChatGPT continues to evolve with plugins like Orpheus, it brings us closer to a future where AI augments our understanding of complex medical concepts and empowers healthcare professionals and researchers with efficient decision support.If you’re eager to explore the frontiers of knowledge-backed AI in biomedicine, connect with us at Wisecube and embark on a journey of discovery and innovation.

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